Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis

The integrity of chromatin, which provides a dynamic template for all DNA-related processes in eukaryotes, is maintained through replication-dependent and -independent assembly pathways. To address the role of histone deposition in the absence of DNA replication, we deleted the H3.3 chaperone Hira i...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Nashun, Buhe, Hill, Peter W.S., Smallwood, Sebastien A., Dharmalingam, Gopuraja, Amouroux, Rachel, Clark, Stephen J., Sharma, Vineet, Ndjetehe, Elodie, Pelczar, Pawel, Festenstein, Richard J., Kelsey, Gavin, Hajkova, Petra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672152/
https://ncbi.nlm.nih.gov/pubmed/26549683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.010
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