De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is accompanied by Ten-Eleven Translocation 3 (Tet3)-driven oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC)(1-4). Here we demonstrate using detailed immunofluorescence analysis and ultra-sensitive LC/MS...

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Publicado no:Nat Cell Biol
Main Authors: Amouroux, Rachel, Nashun, Buhe, Shirane, Kenjiro, Nakagawa, Shoma, Hill, Peter WS, D’Souza, Zelpha, Nakayama, Manabu, Matsuda, Masashi, Turp, Aleksandra, Ndjetehe, Elodie, Encheva, Vesela, Kudo, Nobuaki R, Koseki, Haruhiko, Sasaki, Hiroyuki, Hajkova, Petra
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765106/
https://ncbi.nlm.nih.gov/pubmed/26751286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3296
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