EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model

Understanding the molecular basis of drug resistance and utilising this information to overcome chemoresistance remains a key challenge in oncology. Here we report that survivin, a key protein implicated in drug resistance, is overexpressed in cancer stem cell pool of doxorubicin-resistant breast ca...

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Veröffentlicht in:Theranostics
Hauptverfasser: Wang, Tao, Gantier, Michael P., Xiang, Dongxi, Bean, Andrew G, Bruce, Matthew, Zhou, Shu-Feng, Khasraw, Mustafa, Ward, Alister, Wang, Li, Wei, Ming Q., AlShamaileh, Hadi, Chen, Lijue, She, Xiaodong, Lin, Jia, Kong, Lingxue, Shigdar, Sarah, Duan, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672025/
https://ncbi.nlm.nih.gov/pubmed/26681989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.11692
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