Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers where it acts to promote tumor progression. A STAT3-specific transcription factor decoy has been developed to suppress STAT3 downstream signaling, but a delivery strategy is needed to improve clini...

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Vydáno v:Theranostics
Hlavní autoři: Kopechek, Jonathan A., Carson, Andrew R., McTiernan, Charles F., Chen, Xucai, Hasjim, Bima, Lavery, Linda, Sen, Malabika, Grandis, Jennifer R., Villanueva, Flordeliza S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672019/
https://ncbi.nlm.nih.gov/pubmed/26681983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.12822
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