Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

There are four closely-related dengue virus (DENV) serotypes. Infection with one serotype generates antibodies that may cross-react and enhance infection with other serotypes in a secondary infection. We demonstrated that DENV serotype 2 (DENV2)–specific human monoclonal antibody (HMAb) 2D22 is ther...

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Publicado no:Science
Main Authors: Fibriansah, Guntur, Ibarra, Kristie D., Ng, Thiam-Seng, Smith, Scott A., Tan, Joanne L., Lim, Xin-Ni, Ooi, Justin S. G., Kostyuchenko, Victor A., Wang, Jiaqi, de Silva, Aravinda M., Harris, Eva, Crowe, James E., Lok, Shee-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672004/
https://ncbi.nlm.nih.gov/pubmed/26138979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa8651
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