A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

Dengue virus (DENV), which consists of four serotypes (DENV1-4), infects over 400 million people annually. Previous studies have indicated most human monoclonal antibodies (HMAbs) from dengue patients are cross-reactive and poorly neutralizing. Rare neutralizing HMAbs are usually serotype-specific a...

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Detalhes bibliográficos
Main Authors: Fibriansah, Guntur, Tan, Joanne L, Smith, Scott A, Alwis, Adamberage R, Ng, Thiam-Seng, Kostyuchenko, Victor A, Ibarra, Kristie D, Wang, Jiaqi, Harris, Eva, Silva, Aravinda, Crowe, James E, Lok, Shee-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958310/
https://ncbi.nlm.nih.gov/pubmed/24421336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303404
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