Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP.

Cyclic nucleotide-gated ion channels play a key role in visual excitation and a variety of other signaling pathways. The photoaffinity probe 8-p-azidophenacylthio-cGMP (APT-cGMP) has been developed for structural and functional studies of the cGMP-activated channel of retinal rod outer segments. Usi...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Brown, R L, Gerber, W V, Karpen, J W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46718/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7685123/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5369
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