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Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP.

Cyclic nucleotide-gated ion channels play a key role in visual excitation and a variety of other signaling pathways. The photoaffinity probe 8-p-azidophenacylthio-cGMP (APT-cGMP) has been developed for structural and functional studies of the cGMP-activated channel of retinal rod outer segments. Usi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Brown, R L, Gerber, W V, Karpen, J W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46718/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7685123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5369
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