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Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle

The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of “missing heritability”–the proportion of additive genetic variation not captured by common variants on SNP arrays. Sequence variants in transcri...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Gonzalez-Recio, Oscar, Daetwyler, Hans D., MacLeod, Iona M., Pryce, Jennie E., Bowman, Phil J., Hayes, Ben J., Goddard, Michael E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671594/
https://ncbi.nlm.nih.gov/pubmed/26642058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143945
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