Leveraging population admixture to explain missing heritability of complex traits

Despite recent progress on estimating the heritability explained by genotyped SNPs (h(g)(2)), a large gap between h(g)(2) and estimates of total narrow-sense heritability (h(2)) remains. Explanations for this gap include rare variants, or upward bias in family-based estimates of h(2) due to shared e...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Zaitlen, Noah, Pasaniuc, Bogdan, Sankararaman, Sriram, Bhatia, Gaurav, Zhang, Jianqi, Gusev, Alexander, Young, Taylor, Tandon, Arti, Pollack, Samuela, Vilhjálmsson, Bjarni J., Assimes, Themistocles L., Berndt, Sonja I., Blot, William J., Chanock, Stephen, Franceschini, Nora, Goodman, Phyllis G., He, Jing, Hennis, Anselm JM, Hsing, Ann, Ingles, Sue A., Isaacs, William, Kittles, Rick A., Klein, Eric A., Lange, Leslie A., Nemesure, Barbara, Patterson, Nick, Reich, David, Rybicki, Benjamin A., Stanford, Janet L., Stevens, Victoria L, Strom, Sara S., Whitsel, Eric A, Witte, John S., Xu, Jianfeng, Haiman, Christopher, Wilson, James G., Kooperberg, Charles, Stram, Daniel, Reiner, Alex P., Tang, Hua, Price, Alkes L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244251/
https://ncbi.nlm.nih.gov/pubmed/25383972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3139
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