Leveraging population admixture to explain missing heritability of complex traits

Despite recent progress on estimating the heritability explained by genotyped SNPs (h(g)(2)), a large gap between h(g)(2) and estimates of total narrow-sense heritability (h(2)) remains. Explanations for this gap include rare variants, or upward bias in family-based estimates of h(2) due to shared e...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Genet
Κύριοι συγγραφείς: Zaitlen, Noah, Pasaniuc, Bogdan, Sankararaman, Sriram, Bhatia, Gaurav, Zhang, Jianqi, Gusev, Alexander, Young, Taylor, Tandon, Arti, Pollack, Samuela, Vilhjálmsson, Bjarni J., Assimes, Themistocles L., Berndt, Sonja I., Blot, William J., Chanock, Stephen, Franceschini, Nora, Goodman, Phyllis G., He, Jing, Hennis, Anselm JM, Hsing, Ann, Ingles, Sue A., Isaacs, William, Kittles, Rick A., Klein, Eric A., Lange, Leslie A., Nemesure, Barbara, Patterson, Nick, Reich, David, Rybicki, Benjamin A., Stanford, Janet L., Stevens, Victoria L, Strom, Sara S., Whitsel, Eric A, Witte, John S., Xu, Jianfeng, Haiman, Christopher, Wilson, James G., Kooperberg, Charles, Stram, Daniel, Reiner, Alex P., Tang, Hua, Price, Alkes L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244251/
https://ncbi.nlm.nih.gov/pubmed/25383972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3139
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