Mechanism of brain targeting by dexibuprofen prodrugs modified with ethanolamine-related structures

The first molecular insights into how prodrugs modified with ethanolamine-related structures target the brain were generated using an in vitro BBB model and in situ perfusion technique. Prodrugs were delivered safely and efficiently to the brain through tight interaction with the anionic membrane of...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Li, Yanping, Zhou, Yangyang, Jiang, Jiayu, Wang, Xinyi, Fu, Yao, Gong, Tao, Sun, Xun, Zhang, Zhirong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671119/
https://ncbi.nlm.nih.gov/pubmed/26154870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.160
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