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In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery
AIM: Dexibuprofen, the S(+)-isomer of ibuprofen, is an effective therapeutic agent for the treatment of neurodegenerative disorders. However, its clinical use is hampered by a limited brain distribution. The aim of this study was to design and synthesize brain-targeting dexibuprofen prodrugs and to...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010340/ https://ncbi.nlm.nih.gov/pubmed/22301864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.144 |
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