Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration

Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial (RPE) cells is a crucial causative factor responsible for the onset and progression of AMD. A2E, a major component of toxic lipofuscin implicated in AMD, is d...

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Vydáno v:Cell Death Dis
Hlavní autoři: Zhang, J, Bai, Y, Huang, L, Qi, Y, Zhang, Q, Li, S, Wu, Y, Li, X
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670934/
https://ncbi.nlm.nih.gov/pubmed/26561782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.330
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