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Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101
Aberrant metabolic forms of the prion protein (PrP), membrane-associated (Ctm)PrP and cytosolic (cyPrP) interact with the cytosolic ubiquitin E3 ligase, Mahogunin Ring Finger-1 (MGRN1) and affect lysosomes. MGRN1 also interacts with and ubiquitinates TSG101, an ESCRT-I protein, involved in endocytos...
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| Publicado no: | Cell Death Dis |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4670916/ https://ncbi.nlm.nih.gov/pubmed/26539917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.257 |
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