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Mechanism of activation-induced downregulation of Mitofusin 2 (Mfn2) in human peripheral blood T cells

Mitofusin 2 (Mfn2), a mitochondrial protein, has been shown to have anti-proliferative properties when overexpressed. In this report we have shown that activation of resting human peripheral blood T cells caused downregulation of Mfn2 levels. This downregulation of Mfn2 was blocked by different inhi...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Dasgupta, Asish, Chen, Kuang-Hueih, Munk, Rachel B., Sasaki, Carl Y., Curtis, Jessica, Longo, Dan L., Ghosh, Paritosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670797/
https://ncbi.nlm.nih.gov/pubmed/26566676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501023
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