Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

The gut microbiota plays a key role in host metabolism. Toll-Like Receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5 deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevate...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Singh, Vishal, Chassaing, Benoit, Zhang, Limin, Yeoh, Beng San, Xiao, Xia, Kumar, Manish, Baker, Mark T, Cai, Jingwei, Walker, Rachel, Borkowski, Kamil, Harvatine, Kevin, Singh, Nagendra, Shearer, Gregory C, Ntambi, James M, Joe, Bina, Patterson, Andrew D., Gewirtz, Andrew T., Vijay-Kumar, Matam
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670569/
https://ncbi.nlm.nih.gov/pubmed/26525535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.09.028
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