Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells

Stearoyl-CoA desaturase-1 (SCD1) is a lipogenic enzyme involved in the de novo biosynthesis of oleate (C18:1, n9), a major fatty acid in the phospholipids of lipid bilayers of cell membranes. Accordingly, Scd1KO mice display substantially reduced oleate in cell membranes. An altered SCD1 level was o...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Yeoh, Beng San, Saha, Piu, Singh, Vishal, Xiao, Xia, Ying, Yun, Vanamala, Jairam K., Kennett, Mary J., Harvatine, Kevin J., Joe, Bina, Vijay-Kumar, Matam
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Inflammation, Immunity, Fibrosis, and Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142196/
https://ncbi.nlm.nih.gov/pubmed/27609767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00174.2016
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