Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

The gut microbiota plays a key role in host metabolism. Toll-Like Receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5 deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevate...

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Библиографические подробности
Опубликовано в: :Cell Metab
Главные авторы: Singh, Vishal, Chassaing, Benoit, Zhang, Limin, Yeoh, Beng San, Xiao, Xia, Kumar, Manish, Baker, Mark T, Cai, Jingwei, Walker, Rachel, Borkowski, Kamil, Harvatine, Kevin, Singh, Nagendra, Shearer, Gregory C, Ntambi, James M, Joe, Bina, Patterson, Andrew D., Gewirtz, Andrew T., Vijay-Kumar, Matam
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670569/
https://ncbi.nlm.nih.gov/pubmed/26525535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.09.028
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