Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways

BACKGROUND: The mTORC1-inhibitor everolimus shows limited efficacy in treating patients with gastro-entero-pancreatic or pulmonary neuroendocrine tumors (NETs), and poor outcome in patients with malignant pheochromocytoma or hepatic carcinoma. We speculated that any effect may be enhanced by antogon...

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Pubblicato in:PLoS One
Autori principali: Nölting, Svenja, Maurer, Julian, Spöttl, Gerald, Aristizabal Prada, Elke Tatjana, Reuther, Clemens, Young, Karen, Korbonits, Márta, Göke, Burkhard, Grossman, Ashley, Auernhammer, Christoph J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670204/
https://ncbi.nlm.nih.gov/pubmed/26636335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143830
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