Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways

BACKGROUND: The mTORC1-inhibitor everolimus shows limited efficacy in treating patients with gastro-entero-pancreatic or pulmonary neuroendocrine tumors (NETs), and poor outcome in patients with malignant pheochromocytoma or hepatic carcinoma. We speculated that any effect may be enhanced by antogon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Nölting, Svenja, Maurer, Julian, Spöttl, Gerald, Aristizabal Prada, Elke Tatjana, Reuther, Clemens, Young, Karen, Korbonits, Márta, Göke, Burkhard, Grossman, Ashley, Auernhammer, Christoph J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670204/
https://ncbi.nlm.nih.gov/pubmed/26636335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143830
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