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The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells

Modulation of the redox system in cancer cells has been considered a promising target for anti-cancer therapy. The novel MTH1 inhibitor TH588 proved tremendous potential in terms of cancer cell eradication, yet its specificity has been questioned by recent reports, indicating that TH588 may also ind...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Aristizabal Prada, Elke Tatjana, Orth, Michael, Nölting, Svenja, Spöttl, Gerald, Maurer, Julian, Auernhammer, Christoph
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444855/
https://ncbi.nlm.nih.gov/pubmed/28542590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178375
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