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Short-Term Circadian Disruption Impairs Bile Acid and Lipid Homeostasis in Mice
BACKGROUND & AIMS: Bile acids are physiologic detergents that also activate nuclear receptors to regulate glucose and lipid homeostasis. Cholesterol 7α-hydroxylase (Cyp7a1), the rate-limiting enzyme that converts cholesterol to bile acids, is transcriptionally regulated by bile acids and circadi...
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| Publicado no: | Cell Mol Gastroenterol Hepatol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4669895/ https://ncbi.nlm.nih.gov/pubmed/26645046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.08.003 |
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