In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification

Atopic dermatitis is a chronic inflammatory skin disease with defects in the epidermal barrier. In a cohort of African-American children, a FLG2 nonsense mutation has been associated with the disease. In the epidermis of European patients, the expression of filaggrin-2, the filaggrin-related protein...

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Publicat a:Cell Death Dis
Autors principals: Pendaries, V, Le Lamer, M, Cau, L, Hansmann, B, Malaisse, J, Kezic, S, Serre, G, Simon, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669814/
https://ncbi.nlm.nih.gov/pubmed/25695608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.29
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