Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

Changes of cellular metabolism are an integral property of the malignant potential of most cancer cells. Already in the 1930s, Otto Warburg observed that tumor cells preferably utilize glycolysis and lactate fermentation for energy production, rather than the mitochondrial oxidative phosphorylation...

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Publicado en:Cell Death Dis
Autores principales: Nilsson, H, Lindgren, D, Mandahl Forsberg, A, Mulder, H, Axelson, H, Johansson, M E
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669744/
https://ncbi.nlm.nih.gov/pubmed/25569102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.545
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