The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma

BACKGROUND: Despite recent progress, therapy for metastatic clear cell renal cell carcinoma (CCRCC) is still inadequate. Dysregulated Notch signaling in CCRCC contributes to tumor growth, but the full spectrum of downstream processes regulated by Notch in this tumor form is unknown. METHODOLOGY/PRIN...

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Main Authors: Sjölund, Jonas, Boström, Anna-Karin, Lindgren, David, Manna, Sugata, Moustakas, Aristidis, Ljungberg, Börje, Johansson, Martin, Fredlund, Erik, Axelson, Håkan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149633/
https://ncbi.nlm.nih.gov/pubmed/21826227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023057
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