Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

Loss of the tumor suppressor gene von Hippel–Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to stabilization of the HIF transcription complex, which induces angiogenic and mitogenic pathways essential for tumor formation. Nonetheless, addi...

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Autors principals: Sjölund, Jonas, Johansson, Martin, Manna, Sugata, Norin, Carl, Pietras, Alexander, Beckman, Siv, Nilsson, Elise, Ljungberg, Börje, Axelson, Håkan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129233/
https://ncbi.nlm.nih.gov/pubmed/18079963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32086
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