Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

Loss of the tumor suppressor gene von Hippel–Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to stabilization of the HIF transcription complex, which induces angiogenic and mitogenic pathways essential for tumor formation. Nonetheless, addi...

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Detalhes bibliográficos
Main Authors: Sjölund, Jonas, Johansson, Martin, Manna, Sugata, Norin, Carl, Pietras, Alexander, Beckman, Siv, Nilsson, Elise, Ljungberg, Börje, Axelson, Håkan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129233/
https://ncbi.nlm.nih.gov/pubmed/18079963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32086
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