Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

Loss of the tumor suppressor gene von Hippel–Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to stabilization of the HIF transcription complex, which induces angiogenic and mitogenic pathways essential for tumor formation. Nonetheless, addi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Sjölund, Jonas, Johansson, Martin, Manna, Sugata, Norin, Carl, Pietras, Alexander, Beckman, Siv, Nilsson, Elise, Ljungberg, Börje, Axelson, Håkan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129233/
https://ncbi.nlm.nih.gov/pubmed/18079963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32086
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker