MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

Overexpression of anti-apoptotic BCL-2 family members is a hallmark of many lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) that can be targeted with small molecule inhibitors. ABT-199 is a rationally designed BCL-2 homology (BH)-3 mimetic that spec...

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Vydáno v:Cell Death Dis
Hlavní autoři: Choudhary, G S, Al-harbi, S, Mazumder, S, Hill, B T, Smith, M R, Bodo, J, Hsi, E D, Almasan, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669737/
https://ncbi.nlm.nih.gov/pubmed/25590803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.525
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