Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes

Butyrate, a short-chain fatty acid fiber fermentation product, induces colonocyte apoptosis in part via a Fas-mediated (extrinsic) pathway. In previous studies, we demonstrated that docosahexaenoic acid (DHA, 22:6(Δ4,7,10,13,16,19)) enhances the effect of butyrate by increasing mitochondrial lipid o...

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Bibliografske podrobnosti
izdano v:Am J Physiol Gastrointest Liver Physiol
Main Authors: Kolar, Satya Sree N., Barhoumi, Rola, Callaway, Evelyn S., Fan, Yang-Yi, Wang, Naisyin, Lupton, Joanne R., Chapkin, Robert S.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669682/
https://ncbi.nlm.nih.gov/pubmed/17717041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00312.2007
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