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Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation

DNA methylation and histone acetylation contribute to the transcriptional regulation of genes involved in apoptosis. We have demonstrated that docosahexaenoic acid (DHA, 22:6 n-3) and butyrate enhance colonocyte apoptosis. To determine if DHA and/or butyrate elevate apoptosis through epigenetic mech...

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Autors principals: Cho, Youngmi, Turner, Nancy D, Davidson, Laurie A, Chapkin, Robert S, Carroll, Raymond J, Lupton, Joanne R
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999970/
https://ncbi.nlm.nih.gov/pubmed/24495951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370213514927
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