Despite sequence homologies to gluten, salivary proline-rich proteins do not elicit immune responses central to the pathogenesis of celiac disease

Celiac disease (CD) is an inflammatory disorder triggered by ingested gluten, causing immune-mediated damage to the small-intestinal mucosa. Gluten proteins are strikingly similar in amino acid composition and sequence to proline-rich proteins (PRPs) in human saliva. On the basis of this feature and...

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Veröffentlicht in:Am J Physiol Gastrointest Liver Physiol
Hauptverfasser: Tian, Na, Leffler, Daniel A., Kelly, Ciaran P., Hansen, Joshua, Marietta, Eric V., Murray, Joseph A., Schuppan, Detlef, Helmerhorst, Eva J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
Schlagworte:
Epithelial Biology and Secretion
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669355/
https://ncbi.nlm.nih.gov/pubmed/26505973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00157.2015
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