An oxidative DNA “damage” and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression

In hypoxia, mitochondria-generated reactive oxygen species not only stimulate accumulation of the transcriptional regulator of hypoxic gene expression, hypoxia inducible factor-1 (Hif-1), but also cause oxidative base modifications in hypoxic response elements (HREs) of hypoxia-inducible genes. When...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Lung Cell Mol Physiol
Huvudupphovsmän: Pastukh, Viktor, Roberts, Justin T., Clark, David W., Bardwell, Gina C., Patel, Mita, Al-Mehdi, Abu-Bakr, Borchert, Glen M., Gillespie, Mark N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2015
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669343/
https://ncbi.nlm.nih.gov/pubmed/26432868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00236.2015
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