Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis

BACKGROUND: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk factor for atopic dermatitis (AD) and are known to cause an epidermal barrier defect. The nature of this barrier defect is not fully understood. Patients with AD with FLG LOF mutations are known to ha...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Riethmuller, Christoph, McAleer, Maeve A., Koppes, Sjors A., Abdayem, Rawad, Franz, Jonas, Haftek, Marek, Campbell, Linda E., MacCallum, Stephanie F., McLean, W.H. Irwin, Irvine, Alan D., Kezic, Sanja
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2015
Assuntos:
Atopic Dermatitis and Skin Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669308/
https://ncbi.nlm.nih.gov/pubmed/26071937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.04.042
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