Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis

PURPOSE: Azathioprine (AZA) is widely used as an immunosuppressive drug in autoimmune diseases, but its use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in AZA metabolism. Several clinical guidelines recommend determin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Liu, Yue-Ping, Xu, Han-Qing, Li, Ming, Yang, Xiang, Yu, Shu, Fu, Wei-Ling, Huang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669175/
https://ncbi.nlm.nih.gov/pubmed/26633017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144234
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