Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

Proteolytic processing of the beta-amyloid protein precursor (APP) is regulated by cell-surface receptors. To determine whether neurotransmitter release in response to neuronal activation regulates APP processing in brain, we electrically depolarized superfused rat hippocampal slices and measured so...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Nitsch, R M, Farber, S A, Growdon, J H, Wurtman, R J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506366/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5191
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