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Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

Proteolytic processing of the beta-amyloid protein precursor (APP) is regulated by cell-surface receptors. To determine whether neurotransmitter release in response to neuronal activation regulates APP processing in brain, we electrically depolarized superfused rat hippocampal slices and measured so...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nitsch, R M, Farber, S A, Growdon, J H, Wurtman, R J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46681/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506366/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5191
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