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Therapeutic γ-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms

Pharmacologic augmentation of γ-globin expression sufficient to reduce anemia and clinical severity in patients with diverse hemoglobinopathies has been challenging. In studies here, representative molecules from four chemical classes, representing several distinct primary mechanisms of action, were...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood Cells Mol Dis
मुख्य लेखकों: Dai, Yan, Sangerman, Jose, Hong, Yuan Luo, Fuchareon, Suthat, Chui, David H.K., Faller, Douglas V., Perrine, Susan P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667977/
https://ncbi.nlm.nih.gov/pubmed/26603726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2015.10.004
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