Therapeutic γ-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms

Pharmacologic augmentation of γ-globin expression sufficient to reduce anemia and clinical severity in patients with diverse hemoglobinopathies has been challenging. In studies here, representative molecules from four chemical classes, representing several distinct primary mechanisms of action, were...

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Detaylı Bibliyografya
Yayımlandı:Blood Cells Mol Dis
Asıl Yazarlar: Dai, Yan, Sangerman, Jose, Hong, Yuan Luo, Fuchareon, Suthat, Chui, David H.K., Faller, Douglas V., Perrine, Susan P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667977/
https://ncbi.nlm.nih.gov/pubmed/26603726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2015.10.004
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