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Methadone pharmacogenetics: CYP2B6 polymorphisms determine plasma concentrations, clearance and metabolism
BACKGROUND: Interindividual variability in methadone disposition remains unexplained, and methadone accidental overdose in pain therapy is a significant public health problem. Cytochrome P4502B6 (CYP2B6) is the principle determinant of clinical methadone elimination. The CYP2B6 gene is highly polymo...
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| Veröffentlicht in: | Anesthesiology |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4667947/ https://ncbi.nlm.nih.gov/pubmed/26389554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000867 |
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