Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells

Heat shock protein (HSP)90 inhibitors have shown significant anti-tumor activities in preclinical settings in both solid and hematological tumors. We previously reported that the novel, orally available HSP90α/β inhibitor TAS-116 shows significant anti-MM activities. In this study, we further examin...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Suzuki, Rikio, Kikuchi, Shohei, Harada, Takeshi, Mimura, Naoya, Minami, Jiro, Ohguchi, Hiroto, Yoshida, Yasuhiro, Sagawa, Morihiko, Gorgun, Gullu, Cirstea, Diana, Cottini, Francesca, Jakubikova, Jana, Tai, Yu-Tzu, Chauhan, Dharminder, Richardson, Paul G., Munshi, Nikhil, Ando, Kiyoshi, Utsugi, Teruhiro, Hideshima, Teru, Anderson, Kenneth C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667922/
https://ncbi.nlm.nih.gov/pubmed/26630652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143847
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