Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells

BACKGROUND: Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution. The surface of Leishmania parasites is covered in a dense glycocalyx consisting of primarily lipophosphoglycan...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Favila, Michelle A., Geraci, Nicholas S., Jayakumar, Asha, Hickerson, Suzanne, Mostrom, Janet, Turco, Salvatore J., Beverley, Stephen M., McDowell, Mary Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667916/
https://ncbi.nlm.nih.gov/pubmed/26630499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004238
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