Geometrical Frustration in Interleukin-33 Decouples the Dynamics of the Functional Element from the Folding Transition State Ensemble

Interleukin-33 (IL-33) is currently the focus of multiple investigations into targeting pernicious inflammatory disorders. This mediator of inflammation plays a prevalent role in chronic disorders such as asthma, rheumatoid arthritis, and progressive heart disease. In order to better understand the...

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發表在:PLoS One
Main Authors: Fisher, Kaitlin M., Haglund, Ellinor, Noel, Jeffrey K., Hailey, Kendra L., Onuchic, José N., Jennings, Patricia A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667907/
https://ncbi.nlm.nih.gov/pubmed/26630011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144067
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