ADAR1 Facilitates HIV-1 Replication in Primary CD4(+) T Cells

Unlike resting CD4(+) T cells, activated CD4(+)T cells are highly susceptible to infection of human immunodeficiency virus 1 (HIV-1). HIV-1 infects T cells and macrophages without activating the nucleic acid sensors and the anti-viral type I interferon response. Adenosine deaminase acting on RNA 1 (...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cuadrado, Eloy, Booiman, Thijs, van Hamme, John L., Jansen, Machiel H., van Dort, Karel A., Vanderver, Adeline, Rice, Gillian I., Crow, Yanick J., Kootstra, Neeltje A., Kuijpers, Taco W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667845/
https://ncbi.nlm.nih.gov/pubmed/26629815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143613
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