Phase II Study of CD4(+)-Guided Pentostatin Lymphodepletion and Pharmacokinetically Targeted Busulfan as Conditioning for Hematopoietic Cell Allografting

One limitation of reduced-intensity preparative regimens is potential for graft failure. We have developed a regimen that targets CD4(+) lymphodepletion to ensure early and durable engraftment. The primary endpoint was achievement of ≥50% CD3(+) donor chimerism by day +28. Forty-two patients (median...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Biol Blood Marrow Transplant
Autori principali: Kharfan-Dabaja, Mohamed A., Anasetti, Claudio, Fernandez, Hugo F., Perkins, Janelle, Ochoa-Bayona, Jose L., Pidala, Joseph, Perez, Lia E., Ayala, Ernesto, Field, Teresa, Alsina, Melissa, Nishihori, Taiga, Locke, Frederick, Pinilla-Ibarz, Javier, Tomblyn, Marcie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667782/
https://ncbi.nlm.nih.gov/pubmed/23632090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2013.04.020
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi