Phase II Study of CD4(+)-Guided Pentostatin Lymphodepletion and Pharmacokinetically Targeted Busulfan as Conditioning for Hematopoietic Cell Allografting

One limitation of reduced-intensity preparative regimens is potential for graft failure. We have developed a regimen that targets CD4(+) lymphodepletion to ensure early and durable engraftment. The primary endpoint was achievement of ≥50% CD3(+) donor chimerism by day +28. Forty-two patients (median...

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Bibliografische gegevens
Gepubliceerd in:Biol Blood Marrow Transplant
Hoofdauteurs: Kharfan-Dabaja, Mohamed A., Anasetti, Claudio, Fernandez, Hugo F., Perkins, Janelle, Ochoa-Bayona, Jose L., Pidala, Joseph, Perez, Lia E., Ayala, Ernesto, Field, Teresa, Alsina, Melissa, Nishihori, Taiga, Locke, Frederick, Pinilla-Ibarz, Javier, Tomblyn, Marcie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667782/
https://ncbi.nlm.nih.gov/pubmed/23632090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2013.04.020
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