ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity

Levels of the HER2/ErbB2 protein in the heart are upregulated in some women during breast cancer therapy, and these women are at high risk for developing heart dysfunction after sequential treatment with anti-ErbB2/trastuzumab or doxorubicin. Doxorubicin is known to increase oxidative stress in the...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Belmonte, Frances, Das, Samarjit, Sysa-Shah, Polina, Sivakumaran, Vidhya, Stanley, Brian, Guo, Xin, Paolocci, Nazareno, Aon, Miguel A., Nagane, Masaki, Kuppusamy, Periannan, Steenbergen, Charles, Gabrielson, Kathleen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
Schlagworte:
Signaling and Stress Response
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666964/
https://ncbi.nlm.nih.gov/pubmed/26254336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00517.2014
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