Cardiac-Specific Over-Expression of Epidermal Growth Factor Receptor 2 (ErbB2) Induces Pro-Survival Pathways and Hypertrophic Cardiomyopathy in Mice

BACKGROUND: Emerging evidence shows that ErbB2 signaling has a critical role in cardiomyocyte physiology, based mainly on findings that blocking ErbB2 for cancer therapy is toxic to cardiac cells. However, consequences of high levels of ErbB2 activity in the heart have not been previously explored....

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Detalhes bibliográficos
Main Authors: Sysa-Shah, Polina, Xu, Yi, Guo, Xin, Belmonte, Frances, Kang, Byunghak, Bedja, Djahida, Pin, Scott, Tsuchiya, Noriko, Gabrielson, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415416/
https://ncbi.nlm.nih.gov/pubmed/22912742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042805
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