Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin directly antagonizes cancer cell growth through its actions on complex I of the mitochondrial electron transport chain (ETC). However, the mec...

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Detaylı Bibliyografya
Yayımlandı:PLoS Biol
Asıl Yazarlar: Griss, Takla, Vincent, Emma E., Egnatchik, Robert, Chen, Jocelyn, Ma, Eric H., Faubert, Brandon, Viollet, Benoit, DeBerardinis, Ralph J., Jones, Russell G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666657/
https://ncbi.nlm.nih.gov/pubmed/26625127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002309
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