Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1

Simvastatin (SIM) is anti-inflammatory. We used low density lipoprotein receptor knockout (LDLR-/-) mice and human aortic smooth muscle cells (HASMCs) as model systems to study the effect of SIM on arterial calcification and to explore the potential mechanisms contributing to this protective effect....

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Bibliographic Details
Published in:PLoS One
Main Authors: Lin, Chih-Pei, Huang, Po-Hsun, Lai, Chung Fang, Chen, Jaw-Wen, Lin, Shing-Jong, Chen, Jia-Shiong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666466/
https://ncbi.nlm.nih.gov/pubmed/26625143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143686
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