Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1

Simvastatin (SIM) is anti-inflammatory. We used low density lipoprotein receptor knockout (LDLR-/-) mice and human aortic smooth muscle cells (HASMCs) as model systems to study the effect of SIM on arterial calcification and to explore the potential mechanisms contributing to this protective effect....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lin, Chih-Pei, Huang, Po-Hsun, Lai, Chung Fang, Chen, Jaw-Wen, Lin, Shing-Jong, Chen, Jia-Shiong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666466/
https://ncbi.nlm.nih.gov/pubmed/26625143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143686
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